The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease.
Identifieur interne : 000195 ( Main/Exploration ); précédent : 000194; suivant : 000196The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease.
Auteurs : Joshua Baugh [États-Unis] ; Ute Bartels [Canada] ; James Leach [États-Unis] ; Blaise Jones [États-Unis] ; Brooklyn Chaney [États-Unis] ; Katherine E. Warren [États-Unis] ; Jenavieve Kirkendall [États-Unis] ; Renee Doughman [États-Unis] ; Cynthia Hawkins [Canada] ; Lili Miles [États-Unis] ; Christine Fuller [États-Unis] ; Tim Hassall [Australie] ; Eric Bouffet [Canada] ; Adam Lane [États-Unis] ; Darren Hargrave [Royaume-Uni] ; Jacques Grill [France] ; Lindsey M. Hoffman [États-Unis] ; Chris Jones [Royaume-Uni] ; Alex Towbin [États-Unis] ; Sharon A. Savage [États-Unis] ; Michelle Monje [États-Unis] ; Xiao-Nan Li [États-Unis] ; David S. Ziegler [Australie] ; Sophie Veldhuijzen Van Zanten [Pays-Bas] ; Christof M. Kramm [Allemagne] ; Dannis G. Van Vuurden [Pays-Bas] ; Maryam Fouladi [États-Unis]Source :
- Journal of neuro-oncology [ 1573-7373 ] ; 2017.
Abstract
Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of DIPG. Comprised of comprehensive deidentified but linked clinical, imaging, histopathological, and genomic repositories, the IDIPGR uses standardized case report forms for uniform data collection; serial imaging and histopathology are centrally reviewed by IDIPGR neuro-radiologists and neuro-pathologists, respectively. Tissue and genomic data, and cell cultures derived from autopsies coordinated by the IDIPGR are available to investigators for studies approved by the Scientific Advisory Committee. From April 2012 to December 2016, 670 patients diagnosed with DIPG have been enrolled from 55 participating institutions in the US, Canada, Australia and New Zealand. The radiology repository contains 3558 studies from 448 patients. The pathology repository contains tissue on 81 patients with another 98 samples available for submission. Fresh DIPG tissue from seven autopsies has been sent to investigators to develop primary cell cultures. The bioinformatics repository contains next-generation sequencing data on 66 tumors. Nine projects using data/tissue from the IDIPGR by 13 principle investigators from around the world are now underway. The IDIPGR, a successful alliance among philanthropic agencies and investigators, has developed and maintained a highly collaborative, hypothesis-driven research infrastructure for interdisciplinary and translational projects in DIPG to improve diagnosis, response assessment, treatment and outcome for patients.
DOI: 10.1007/s11060-017-2372-5
PubMed: 28093680
Affiliations:
- Allemagne, Australie, Canada, France, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Basse-Saxe, Californie, Grand Londres, Hollande-Septentrionale, Maryland, Ohio, Texas
- Amsterdam, Göttingen, Londres
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Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name><affiliation wicri:level="1"><nlm:affiliation>Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Leach, James" sort="Leach, James" uniqKey="Leach J" first="James" last="Leach">James Leach</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Jones, Blaise" sort="Jones, Blaise" uniqKey="Jones B" first="Blaise" last="Jones">Blaise Jones</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Chaney, Brooklyn" sort="Chaney, Brooklyn" uniqKey="Chaney B" first="Brooklyn" last="Chaney">Brooklyn Chaney</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country 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type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Doughman, Renee" sort="Doughman, Renee" uniqKey="Doughman R" first="Renee" last="Doughman">Renee Doughman</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Hawkins, Cynthia" sort="Hawkins, Cynthia" uniqKey="Hawkins C" first="Cynthia" last="Hawkins">Cynthia Hawkins</name><affiliation wicri:level="1"><nlm:affiliation>Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Miles, Lili" sort="Miles, Lili" uniqKey="Miles L" first="Lili" last="Miles">Lili Miles</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Fuller, Christine" sort="Fuller, Christine" uniqKey="Fuller C" first="Christine" last="Fuller">Christine Fuller</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Hassall, Tim" sort="Hassall, Tim" uniqKey="Hassall T" first="Tim" last="Hassall">Tim Hassall</name><affiliation wicri:level="1"><nlm:affiliation>Lady Cilento Children's Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lady Cilento Children's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation wicri:level="1"><nlm:affiliation>Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lane, Adam" sort="Lane, Adam" uniqKey="Lane A" first="Adam" last="Lane">Adam Lane</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Hargrave, Darren" sort="Hargrave, Darren" uniqKey="Hargrave D" first="Darren" last="Hargrave">Darren Hargrave</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Hospital for Children NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Hospital for Children NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy Institute, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy Institute, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Hoffman, Lindsey M" sort="Hoffman, Lindsey M" uniqKey="Hoffman L" first="Lindsey M" last="Hoffman">Lindsey M. Hoffman</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Towbin, Alex" sort="Towbin, Alex" uniqKey="Towbin A" first="Alex" last="Towbin">Alex Towbin</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Savage, Sharon A" sort="Savage, Sharon A" uniqKey="Savage S" first="Sharon A" last="Savage">Sharon A. Savage</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Monje, Michelle" sort="Monje, Michelle" uniqKey="Monje M" first="Michelle" last="Monje">Michelle Monje</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University and Lucile Packard Children's Hospital, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University and Lucile Packard Children's Hospital, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Li, Xiao Nan" sort="Li, Xiao Nan" uniqKey="Li X" first="Xiao-Nan" last="Li">Xiao-Nan Li</name><affiliation wicri:level="2"><nlm:affiliation>Texas Children's Hospital, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Texas Children's Hospital, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ziegler, David S" sort="Ziegler, David S" uniqKey="Ziegler D" first="David S" last="Ziegler">David S. Ziegler</name><affiliation wicri:level="1"><nlm:affiliation>Sydney Children's Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Children's Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Veldhuijzen Van Zanten, Sophie" sort="Veldhuijzen Van Zanten, Sophie" uniqKey="Veldhuijzen Van Zanten S" first="Sophie" last="Veldhuijzen Van Zanten">Sophie Veldhuijzen Van Zanten</name><affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M" last="Kramm">Christof M. Kramm</name><affiliation wicri:level="3"><nlm:affiliation>University of Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Van Vuurden, Dannis G" sort="Van Vuurden, Dannis G" uniqKey="Van Vuurden D" first="Dannis G" last="Van Vuurden">Dannis G. Van Vuurden</name><affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA. maryam.fouladi@cchmc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neuro-oncology</title><idno type="eISSN">1573-7373</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of DIPG. Comprised of comprehensive deidentified but linked clinical, imaging, histopathological, and genomic repositories, the IDIPGR uses standardized case report forms for uniform data collection; serial imaging and histopathology are centrally reviewed by IDIPGR neuro-radiologists and neuro-pathologists, respectively. Tissue and genomic data, and cell cultures derived from autopsies coordinated by the IDIPGR are available to investigators for studies approved by the Scientific Advisory Committee. From April 2012 to December 2016, 670 patients diagnosed with DIPG have been enrolled from 55 participating institutions in the US, Canada, Australia and New Zealand. The radiology repository contains 3558 studies from 448 patients. The pathology repository contains tissue on 81 patients with another 98 samples available for submission. Fresh DIPG tissue from seven autopsies has been sent to investigators to develop primary cell cultures. The bioinformatics repository contains next-generation sequencing data on 66 tumors. Nine projects using data/tissue from the IDIPGR by 13 principle investigators from around the world are now underway. The IDIPGR, a successful alliance among philanthropic agencies and investigators, has developed and maintained a highly collaborative, hypothesis-driven research infrastructure for interdisciplinary and translational projects in DIPG to improve diagnosis, response assessment, treatment and outcome for patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Californie</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Maryland</li><li>Ohio</li><li>Texas</li></region><settlement><li>Amsterdam</li><li>Göttingen</li><li>Londres</li></settlement></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Baugh, Joshua" sort="Baugh, Joshua" uniqKey="Baugh J" first="Joshua" last="Baugh">Joshua Baugh</name></region><name sortKey="Chaney, Brooklyn" sort="Chaney, Brooklyn" uniqKey="Chaney B" first="Brooklyn" last="Chaney">Brooklyn Chaney</name><name sortKey="Doughman, Renee" sort="Doughman, Renee" uniqKey="Doughman R" first="Renee" last="Doughman">Renee Doughman</name><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><name sortKey="Fuller, Christine" sort="Fuller, Christine" uniqKey="Fuller C" first="Christine" last="Fuller">Christine Fuller</name><name sortKey="Hoffman, Lindsey M" sort="Hoffman, Lindsey M" uniqKey="Hoffman L" first="Lindsey M" last="Hoffman">Lindsey M. Hoffman</name><name sortKey="Jones, Blaise" sort="Jones, Blaise" uniqKey="Jones B" first="Blaise" last="Jones">Blaise Jones</name><name sortKey="Kirkendall, Jenavieve" sort="Kirkendall, Jenavieve" uniqKey="Kirkendall J" first="Jenavieve" last="Kirkendall">Jenavieve Kirkendall</name><name sortKey="Lane, Adam" sort="Lane, Adam" uniqKey="Lane A" first="Adam" last="Lane">Adam Lane</name><name sortKey="Leach, James" sort="Leach, James" uniqKey="Leach J" first="James" last="Leach">James Leach</name><name sortKey="Li, Xiao Nan" sort="Li, Xiao Nan" uniqKey="Li X" first="Xiao-Nan" last="Li">Xiao-Nan Li</name><name sortKey="Miles, Lili" sort="Miles, Lili" uniqKey="Miles L" first="Lili" last="Miles">Lili Miles</name><name sortKey="Monje, Michelle" sort="Monje, Michelle" uniqKey="Monje M" first="Michelle" last="Monje">Michelle Monje</name><name sortKey="Savage, Sharon A" sort="Savage, Sharon A" uniqKey="Savage S" first="Sharon A" last="Savage">Sharon A. Savage</name><name sortKey="Towbin, Alex" sort="Towbin, Alex" uniqKey="Towbin A" first="Alex" last="Towbin">Alex Towbin</name><name sortKey="Warren, Katherine E" sort="Warren, Katherine E" uniqKey="Warren K" first="Katherine E" last="Warren">Katherine E. Warren</name></country><country name="Canada"><noRegion><name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name></noRegion><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><name sortKey="Hawkins, Cynthia" sort="Hawkins, Cynthia" uniqKey="Hawkins C" first="Cynthia" last="Hawkins">Cynthia Hawkins</name></country><country name="Australie"><noRegion><name sortKey="Hassall, Tim" sort="Hassall, Tim" uniqKey="Hassall T" first="Tim" last="Hassall">Tim Hassall</name></noRegion><name sortKey="Ziegler, David S" sort="Ziegler, David S" uniqKey="Ziegler D" first="David S" last="Ziegler">David S. Ziegler</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hargrave, Darren" sort="Hargrave, Darren" uniqKey="Hargrave D" first="Darren" last="Hargrave">Darren Hargrave</name></region><name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name></country><country name="France"><noRegion><name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Veldhuijzen Van Zanten, Sophie" sort="Veldhuijzen Van Zanten, Sophie" uniqKey="Veldhuijzen Van Zanten S" first="Sophie" last="Veldhuijzen Van Zanten">Sophie Veldhuijzen Van Zanten</name></region><name sortKey="Van Vuurden, Dannis G" sort="Van Vuurden, Dannis G" uniqKey="Van Vuurden D" first="Dannis G" last="Van Vuurden">Dannis G. Van Vuurden</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M" last="Kramm">Christof M. Kramm</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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